‘BugView’ is a standalone genome browser for comparing the arrangement of genes on a pair of related genomes, although it can also be used to view individual genomes. It was written for comparative studies of bacterial genomes — hence the name — although it handles intron-containing eukaryotic chromosomes equally well. As a desktop application, rather than a web facility, ‘BugView’ responds quickly to adjustment of the visualization, the user has control over file input (GenBank format is used), and views of the genomes can easily be printed or saved.
Click on the thumbnails below for screen-shots illustrating some of the visualizations that ‘BugView’ provides.
Comparison of bacterial genomes
Horizontal presentation of genes colour-coded by COG category
Splice variants in human chromosome 21
Matrix comparison of genomes
A short description of ‘BugView’ was published as an application note in Bioinformatics (2004) 20, 129-130. It was also discussed, with further illustrations of its use, in The Biochemist (2004) 26, 7-11. There is a more extensive article about ‘BugView’ in Methods in Molecular Biology (2007) 395, 109–132, which includes a description of the applet version. (The Grid facility mentioned in that article is, unfortunately, no longer available.)
‘BugView’ is available for the operating systems listed below. A run-time version of Java is required, and can be downloaded from Oracle.
It helps to read the manual before using the program:
The Perl script, gcfprep, used in conjunction with standalone BLAST from NCBI, is also available.
‘Bug View’ was developed by David P. Leader. It incorporates some code written by Andrei Grigoriev for the original ‘Der Browser’ Java applet.